Detecting Folding Intermediates of a Protein as It Passes through the Bacterial Translocation Channel
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چکیده
منابع مشابه
Detecting Folding Intermediates of a Protein as It Passes through the Bacterial Translocation Channel
Most bacterial exported proteins cross the cytoplasmic membrane as unfolded polypeptides. However, little is known about how they fold during or after this process due to the difficulty in detecting folding intermediates. Here we identify cotranslational and posttranslational folding intermediates of a periplasmic protein in which the protein and DsbA, a periplasmic disulfide bond-forming enzym...
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ژورنال
عنوان ژورنال: Cell
سال: 2009
ISSN: 0092-8674
DOI: 10.1016/j.cell.2009.07.030